The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder

 The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder 

The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder

refractory period

 The refractory period is a state of recovery that occurs after a neuron has fired an action potential. 

During this period, another action potential cannot be easily produced. 

This encourages unidirectional flow of action potentials because they cannot travel backwards to inactive neurons.

The depolarization that produces Na+ channel opening also causes delayed activation of K+ channels and Na+ channel inactivation, leading to repolarization of the membrane potential as the action potential sweeps along the length of an axon (see Figure 3.12). In its wake, the action potential leaves the Na+ channels inactivated and K+ channels activated for a brief time. These transitory changes make it harder for the axon to produce subsequent action potentials during this interval, which is called the refractory period. Thus, the refractory period limits the number of action potentials that a given nerve cell can produce per unit time. As might be expected, different types of neurons have different maximum rates of action potential firing due to different types and densities of ion channels. The refractoriness of the membrane in the wake of the action potential explains why action potentials do not propagate back toward the point of their initiation as they travel along an axon.

What happens during the refractory period of a neuron?

In its wake, the action potential leaves the Na+ channels inactivated and K+ channels activated for a brief time. These transitory changes make it harder for the axon to produce subsequent action potentials during this interval, which is called the refractory period.

By definition, the refractory period is a period of time during which a cell is incapable of repeating an action potential. In terms of action potentials, it refers to the amount of time it takes for an excitable membrane to be ready to respond to a second stimulus once it returns to a resting state.