Wednesday, May 22, 2024

Week 3 practice question

 Question 1

/ 1 pts

Chlorpromazine (marketed under brand names Thorazine and Largactil) is a drug used to treat psychotic disorders such as schizophrenia or manic-depression in adults. Chlorpromazine was developed in the 1950s and its introduction as the first antipsychotic on the market has been labeled as one of the great advances in the history of psychiatry.

Chlorpromazine blocks postsynaptic receptors for several different neurotransmitters, such as dopamine and serotonin. Predict the effect of chlorpromazine on synaptic transmission by selecting all of the steps it will directly inhibit in the picture below.

Screen Shot 2022-08-26 at 10.45.58 AM.png

  
  
  
  
  
 
Question 2
/ 1 pts
Some neurotransmitter receptors are ion channels that open when the neurotransmitter binds to them. Those receptors are called:
  
  
  
  
 
Question 3
/ 1 pts

Funnel-web spiders are found in southeast Australia, around Sydney. Others are found in Europe, New Zealand, and Chile. They are not native to the United States, although some people may keep them as exotic pets.

Their bites are very painful and dangerous. They have been known to cause serious symptoms, such as agitation, confusion, numbness of mouth and lips, and even coma and death.

Funnel-web spider venom is a neurotoxin that blocks gated calcium channels. Its effect would be a/an:

  
  
  
  
 
Question 4
/ 1 pts

Identify the ion that would move through the channel to produce an IPSP.

Ions 1-3 are in the extracellular fluid (blue background),  ions 4-6 are in the cytosol (yellow background). Figure out which ion and which direction it would flow based on what you know about concentration gradients for each ion.

Screen Shot 2022-08-26 at 10.53.19 AM.png

  
  
  
 
Question 5
/ 1 pts
One type of channel involved in generating postsynaptic potentials at a chemical synapse is the:
  
  
  
  
 
Question 6
/ 1 pts
Screen Shot 2022-08-26 at 11.01.39 AM.pngSelective serotonin reuptake inhibitors (or SSRIs), such as Prozac, Celexa, Lexapro, Paxil, and Zoloft, are a class of drugs used to treat mood disorders such as depression and anxiety. They inhibit the transporter responsible for serotonin reuptake into the presynaptic neuron. What is the effect of the SSRIs on the serotonin concentration in the synaptic cleft?
  
Correct. When reuptake is inhibited, more serotonin stays in the cleft longer and is available to stimulate postsynaptic neurons. Since mood disorders often correlate with reduced serotonin availability and receptor stimulation, SSRIs are effective in helping patients who suffer from these disorders.
  
 
Question 7
/ 1 pts
Which of the following does NOT happen to neurotransmitters during synaptic transmission termination?
  
  
  
  
 
Question 8
/ 1 pts

Use what you learned during the Lecture 3 handout.

Cocaine is a powerfully addictive stimulant drug made from the leaves of the coca plant native to South America. As a street drug, cocaine looks like a fine, white, crystal powder or it is processed to a make rock crystal.

Cocaine acts as a dopamine reuptake inhibitor. Therefore, cocaine will:

  
  
Correct. Less reuptake means more dopamine remains in the cleft and is available to stimulate dopamine receptors.
  
  
 
Question 9
/ 1 pts
During the absolute refractory period, the axon membrane:
  
  
  
  
 
Question 10
/ 1 pts
The refractory period of an action potential...
  
  
  
  
 
Question 11
/ 1 pts
The faster, more efficient way of propagating an action potential is:
  
  
  
  
 
Question 12
/ 1 pts
The threshold potential is best defined as the potential at which...
  
  
  
  
 
Question 13
/ 1 pts
Action potentials self-propagate because...
  
  
  
  

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