Saturday, April 27, 2024

Myelin

Axons which are covered by a myelin sheath, a multilayer of proteins and lipids, are said to be myelinated. 
Myelin Sheath Function
The myelin sheath acts as electrical insulation around axons, preventing signal loss and ensuring efficient transmission of nerve impulses.


  • Fatty, insulating layer which covers a neuron and speeds up electrical signals. Forms the white matter in the CNS
  1. Axon
  2. Dendrite
  3. Myelin
  4. Synapse
Astrocytes -support neurons in the central nervous system are by maintaining the concentration of chemicals in the extracellular space, removing excess signaling molecules, reacting to tissue damage, and contributing to the blood-brain barrier (BBB) 

review question

  Which of the following cavities contains a component of the central nervous system?

  1. abdominal
  2. pelvic
  3. cranial
  4. thoracic

10. Which structure predominates in the white matter of the brain?

  1. myelinated axons
  2. neuronal cell bodies
  3. ganglia of the parasympathetic nerves
  4. bundles of dendrites from the enteric nervous system

11. Which part of a neuron transmits an electrical signal to a target cell?

  1. dendrites
  2. soma
  3. cell body
  4. axon

12. Which term describes a bundle of axons in the peripheral nervous system?

  1. nucleus
  2. ganglion
  3. tract
  4. nerve

13. Which functional division of the nervous system would be responsible for the physiological changes seen during exercise (e.g., increased heart rate and sweating)?

  1. somatic
  2. autonomic
  3. enteric
  4. central

14. What type of glial cell provides myelin for the axons in a tract?

  1. oligodendrocyte
  2. astrocyte
  3. Schwann cell
  4. satellite cell

15. Which part of a neuron contains the nucleus?

  1. dendrite
  2. soma
  3. axon
  4. synaptic end bulb

16. Which of the following substances is least able to cross the blood-brain barrier?

water

sodium ions

glucose

white blood cells

17. What type of glial cell is the resident macrophage behind the blood-brain barrier?

microglia

astrocyte

Schwann cell

satellite cell

18. What two types of macromolecules are the main components of myelin?

  1. carbohydrates and lipids
  2. proteins and nucleic acids
  3. lipids and proteins
  4. carbohydrates and nucleic acids

19. If a thermoreceptor is sensitive to temperature sensations, what would a chemoreceptor be sensitive to?

light

sound

molecules

vibration

20. Which of these locations is where the greatest level of integration is taking place in the example of testing the temperature of the shower?

skeletal muscle

spinal cord

thalamus

cerebral cortex

21. How long does all the signaling through the sensory pathway, within the central nervous system, and through the motor command pathway take?

1 to 2 minutes

1 to 2 seconds

fraction of a second

varies with graded potential

22. What is the target of an upper motor neuron?

cerebral cortex

lower motor neuron

skeletal muscle

thalamus

23. What ion enters a neuron causing depolarization of the cell membrane?

sodium

chloride

potassium

phosphate

24. Voltage-gated Na+ channels open upon reaching what state?

resting potential

threshold

repolarization

overshoot

25. What does a ligand-gated channel require in order to open?

increase in concentration of Na+ ions

binding of a neurotransmitter

increase in concentration of K+ ions

depolarization of the membrane

26. What does a mechanically gated channel respond to?

physical stimulus

chemical stimulus

increase in resistance

decrease in resistance

27. Which of the following voltages would most likely be measured during the relative refractory period?

+30 mV

0 mV

-45 mV

-80 mv

28. Which of the following is probably going to propagate an action potential fastest?

a thin, unmyelinated axon

a thin, myelinated axon

a thick, unmyelinated axon

a thick, myelinated axon

29. How much of a change in the membrane potential is necessary for the summation of postsynaptic potentials to result in an action potential being generated?

+30 mV

+15 mV

+10 mV

-15 mV

30. A channel opens on a postsynaptic membrane that causes a negative ion to enter the cell. What type of graded potential is this?

depolarizing

repolarizing

hyperpolarizing

non-polarizing

31. What neurotransmitter is released at the neuromuscular junction?

norepinephrine

serotonin

dopamine

acetylcholine

32. What type of receptor requires an effector protein to initiate a signal?

biogenic amine

ionotropic receptor

cholinergic system

metabotropic receptor

33. Which of the following neurotransmitters is associated with inhibition exclusively?

GABA

acetylcholine

glutamate

norepinephrine


metabotropic receptor. The metabotropic receptor \textit{metabotropic receptor} metabotropic receptor requires an effector protein to initiate the signal.

Neuron action potential - physiology

Function of nervous system


The functions of the nervous system—sensation, integration, and response—depend on the functions of the neurons underlying these pathways. 


Ligand Gated Ion Channels | Nervous system physiology | NCLEX-RN | Khan ...

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Ion Channel Types

12.3 The Function of Nervous Tissue

  •  the major functions of the nervous system: sensation, integration, and response.
  •  Testing the Water: 
  1.  The sensory neuron has endings in the skin that sense a stimulus such as water temperature. The strength of the signal that starts here is dependent on the strength of the stimulus.
  2.   The graded potential from the sensory endings, if strong enough, will initiate an action potential at the initial segment of the axon (which is immediately adjacent to the sensory endings in the skin). 
  3.  The axon of the peripheral sensory neuron enters the spinal cord and contacts another neuron in the gray matter. 
  4. The contact is a synapse where another graded potential is caused by the release of a chemical signal from the axon terminals.
  5.  An action potential is initiated at the initial segment of this neuron and travels up the sensory pathway to a region of the brain called the thalamus
  6. Another synapse passes the information along to the next neuron. 
  7.  The sensory pathway ends when the signal reaches the cerebral cortex. 
  8. After integration with neurons in other parts of the cerebral cortex, a motor command is sent from the precentral gyrus of the frontal cortex.
  9. The upper motor neuron sends an action potential down to the spinal cord. The target of the upper motor neuron is the dendrites of the lower motor neuron in the gray matter of the spinal cord. 
  10.  The axon of the lower motor neuron emerges from the spinal cord in a nerve and connects to a muscle through a neuromuscular junction to cause contraction of the target muscle.
  • Found in the skin of your fingers or toes is a type of sensory receptor that is sensitive to temperature, called a thermoreceptor .
  • The amount of change is dependent on the strength of the stimulus (how hot the water is). This is called a graded potential
  • . If the stimulus is strong, the voltage of the cell membrane will change enough to generate an electrical signal that will travel down the axon. You have learned about this type of signaling before, with respect to the interaction of nerves and muscles at the neuromuscular junction. The voltage at which such a signal is generated is called the threshold, and the resulting electrical signal is called an action potential
  • In this example, the action potential travels—a process known as propagation—along the axon from the axon hillock to the axon terminals and into the synaptic end bulbs.
  • When this signal reaches the end bulbs, it causes the release of a signaling molecule called a neurotransmitter
When the molecular signal binds to the receptor, the cell membrane of the target neuron changes its electrical state and a new graded potential begins.
  • If graded potential is strong enough to reach threshold, the second neuron generates an action potential at its axon hillock
The upper motor neuron is in this region, called the precentral gyrus of the frontal cortex, which has an axon that extends all the way down the spinal cord. 
  • At the level of the spinal cord at which this axon makes a synapse, a graded potential occurs in the cell membrane of a lower motor neuron.
  • This second motor neuron is responsible for causing muscle fibers to contract.
  • The axon terminates on muscle fibers at the neuromuscular junction.
  • Acetylcholine is released at this specialized synapse, which causes the muscle action potential to begin, following a large potential known as an end plate potential.

quizlet

 Definition

A fast and automatic response to immediate danger
Stimulus
Synapse
Reflex
Neuron
1 of 20
Definition
Connects the left and right hemispheres of the brain
Cerebellum
Corpus callosum
Hypothalamus
Thalamus
2 of 20
Definition
The chemical which is released from an axon terminal and travels across a synapse to the next neuron
Synapse
Neurotransmitter
Axon
Dendrite
3 of 20
Definition
Receptors that detect movement eg. touch, hearing
Hypothalamus
Axon
Nociceptors
Mechanoreceptors
4 of 20
Definition
Receptors that detect chemicals eg. taste, smell
Hypothalamus
Chemoreceptors
Photoreceptors
Sensory
5 of 20
Definition
The gap between 2 neurons across which chemical neurotransmitters travel to reach the next neuron
Axon
Synapse
Dendrite
Thalamus
6 of 20
Definition
Forms part of the Central Nervous System along with the brain.
Brain stem
Spinal cord
Cerebellum
Thalamus
7 of 20
Definition
Cell body
Cerebellum
Corpus callosum
Brain stem
8 of 20
Definition
The set of motor nerves that automatically control the operation of vital glands and organs; also called the involuntary nervous system
Sensory
Brain
Autonomic
Motor
9 of 20
Definition
Synapse
Cell body
Axon terminal
Dendrite
10 of 20
Definition
Part of the brain that processes information relating to well being of the body
maintains homeostasis (body balance)
Cerebellum
Hypothalamus
Brain
Synapse
11 of 20
Definition
Synapse
Cell body
Brain stem
Axon
12 of 20
Definition
Type of neuron which receives signals from the CNS and sends messages to effectors
Motor
Hypothalamus
Autonomic
Sensory
13 of 20
Definition
Frontal lobe
Brain stem
Dendrite
Cell body
14 of 20
Definition
sitting close to ear level within the skull it is associated with processing auditory information and with the encoding of memory.
Myelin
Axon
Frontal Lobe
Temporal Lobe
15 of 20
Definition
Forms part of the Central Nervous System along with the spinal cord.
Spinal Cord
Hypothalamus
Cerebrum
Brain
16 of 20
Definition
Brain stem
Corpus callosum
Frontal lobe
Cell body
17 of 20
Definition
Part of a neuron responsible for normal cell function
Axon terminal
Axon
Myelin sheath
Cell body
18 of 20
Definition
White matter is found on the inside of the brain and the outside of the spinal cord. It is made up of this part of the neuron
Axon
Dendrite
Myelin sheath
Cell body
19 of 20
Definition
Nervous system responses are FAST/SLOW
Myelin
Slow
Electrical
Fast