Week 8 Resources & Notes

 Note on Pre-Class materials for blood vessels & capillary exchange

• Post class slidesDownload Post class slides
• recording from previous quarters you can access if you want to rewatch outside of the playposit thingLinks to an external site.
• Additional resources:
  • Reminder that a textbook version of this material can be found on openstax if you prefer to read the material: 20.1-20.4 (Links to an external site.with an emphasis on 20.2 and 20.3)
  • I'm sort of hesistant to share because I think it's an overwhelming amount of info (and way more detail than we went into because again I tried to cut a lot down):
    • My colleague Giorgio Lagna put together this slideshow deck from the Amerman textbook Download slideshow deck from the Amerman textbookthat is slightly nicer in explaining than openstax I think?
    • I am sharing it because I think it could be helpful to use the "find" function to look up specific terms if my explanation wasn't sufficient for you during the recorded lecture. If you do take a look, can you send me a note or tell me in lecture, is this sort of thing helpful or do you hate it?

Lecture 8: Blood pressure & hemodynamics

Friday May 31

• SlidesDownload Slides
• HandoutDownload Handout
  • Please submit your online exit ticket here
• Post class slidesDownload Post class slides
  • please see notes (blue slides) regarding extra credit opportunity on upcoming Midterm 2
• RecordingLinks to an external site.

 

Guided questions from this week

1. Describe the anatomy of a general blood vessel. What are the functions of each of the layers?
   1. Describe the characteristics and functions of arteries, arterioles, capillaries (all three types), venules and veins.
   2. Explain how the elastic recoil of arteries contributes to maintaining blood flow.
2. Give a general description of how exchange happens in capillaries. How does that exchange work differently in continuous capillaries, fenestrated capillaries and discontinuous capillaries?
   1. What is exchange by bulk flow and how is it different than exchange by diffusion?
   2. Differentiate between reabsorption and filtration.
   3. Describe the following pressures, what causes them, and whether they favor filtration or reabsorption: Blood hydrostatic pressure, interstitial fluid osmotic pressure, blood colloid osmotic pressure, and net filtration pressure.
   4. Describe the process of exchange across a capillary as it relates to the three pressures mentioned in the question above. How does exchange differ at the arterial end of a capillary vs. the venous end?
3. What factors affect blood pressure?
   1. Define blood pressure, pulse, pulse pressure, mean arterial pressure
      and peripheral resistance
   2. Give the ranges for a healthy diastolic and systolic blood pressure.
4. How does cardiac output (or stroke volume x HR) affect MAP?
   1. How does total peripheral resistance affect MAP?
   2. What are the three factors that contribute to total peripheral resistance? Which of these is altered most easily and most often to affect MAP?
   3. How is total peripheral resistance altered systemically? (think about sympathetic vs parasympathetic responses)
      Be sure to talk about what neurotransmitters/receptors and/or hormones are involved
   4. Describe active hyperemia (excess of blood in vessels supplying oxygen to organs). When does this process take place? What are the stimuli for vasodilation.
5. What are baroreceptors and where are they found?
   
   1. How do blood pressure changes alter the number of action potentials sent to the cardiovascular control center
   2. Draw a flow chart diagramming the systemic response to increased blood pressure
   3. Draw a flow chart diagramming the systemic response to decreased blood pressure
      
      
6. How do changes in blood volume alter stroke volume? Cardiac output? MAP?
   1. How does the body compensate for low blood volume?
      
      
7. What is hypertension? What are the dangers of hypertension?
   1. Explain how atherosclerosis develops and the dangers it presents.
   2. List several treatments for high blood pressure and delineate their mechanisms of action
      
      
8. Be familiar with the equations we discussed in class including how to calculate NFP, cardiac output, and MAP.
   
   1. The other equations provided were to summarize concepts we have already talked about all throughout this class (factors that impact resistance and blood pressure, conceptually what determines stroke volume, etc.). If the equations work for you as a quick reference, use them. If they don't, then go with the analogies we discussed throughout class (thick vs thin straws/pinched or unpiched hoses, milkshake vs. soda as fluid, etc.).

 

Note 1: Total peripheral resistance (TPR) is also called systemic vascular resistance (SVR). I thought I'd let you know in case you are using other resources to study!